The study was published in thepeer reviewed medical journal, Science Translational Medicine.
The pulp (the middle soft part of the tooth containing the nerve, blood supply and connective tissue) of two molar teeth was exposed in seven rats. One of the teeth was given low power laser therapy, whilethe other was not and acted as a control.
Stem cell research so far has involved stimulating stem cells to turn into particular tissues, either ina laboratory setting when the tissues are thentransplanted, or by stimulating the cells in the body using chemicals.
Researchers performed experiments on human dental stem cells to see if laser therapy would stimulate them to produce dentin. They also performed experiments on rodents to see whether laser therapy could increase dentin formation in damaged teeth.
Further studies in genetically modified mice and with chemicals meant the researchers found that low power laser therapy generates free radicals, which activated TGF 1.
Laser therapy did cause the dental stem cells to grow dentin in human tissue samples and rodents. However, it did not cause the growth of any other cell required to make teeth, such as the hard layer of enamel, whichprotects teeth against damage.
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A new laboratory study has found that low power laser therapy can stimulate dental stem cells (cells that have the ability to form into other specialised tooth cells) to create dentin, the tooth layer under enamel.
Stem cells are present throughout the body. When they divide, they are capable of replacing themselves with another stem cell while producing cells thattake on a specialised form,such asa nerve cell or a skin cell.
immediate or medium term use in dentistry, was well reported by the BBC News and Mail Online websites.
The stem cells may have started to change into a certain tissue type such as dental stem cells but then lie dormant until they are stimulated to turn into the required type of dental cell.
are guilty of spreading the inaccurate claim that root canal treatment is a painful treatment.
The teeth were then given a filling and the researchers measured the level of recovery, as demonstrated by dentin formation, after 12 weeks.
Laser therapy has so far been used to destroy unwanted or damaged cells, such as cancers and tattoos. However, low power laser therapy (or low power light therapy) has been found to reduce pain and inflammation, and promote wound healing.
Low power laser therapy was found to stimulate free radical production (reactive oxygen species) in mink lung cells, mouse dental pulp cells and the serum of foetal calves in the laboratory.
"Lasers have been used to regenerate parts of damaged teeth," BBC News reports. The hope is that laser therapy could one day replace lengthy and expensive dental operations such as root canal treatments.
having a filling.
Other experiments were performed to investigate the molecular processes that occur after low power laser therapy.
The study, and the fact thatitsfindings will not beof Nike Force Mid Winter Mens Trainers
What were the basic results?In the first experiment in rats, low power laser therapy stimulated increased amounts of dentinafter 12 weeks compared with the control.
Both techniques have potential side effects and limitations. The researchers wanted to see if they could stimulate dental stem cells to grow into dentin forming cells just by using laser therapy.
What kind of research was this?This laboratory study of human stem cells, rats and mice aimed to see if low power laser therapy could stimulate stem cells to regenerate dentin, the tooth layer under enamel.
Other changes included the activation of transforming growth factor 1 (TGF 1), a signalling molecule. Signalling molecules transmit information from one cell to another and can often change cell behaviour (often referred to as a cascading effect).
Thankstotechnical advances, root canal treatment is now much less painful than it was 20 to 30 years ago. Albeit not the most enjoyable way of spending a few hours, you will be offered local anaesthetic, so it should be no more uncomfortable than Nike Air Force One Low Black And White
Lasers used to regenerate damaged teeth
In humans, stem cells are constantly being stimulated to turn into cells that replace damaged cells or shortlived cells, such as blood cells and cells that line the gut.
Butthis research is still a long way from providing an alternative to invasive procedures such as root canal treatment.
However, for other types of cells, such as those found in teeth, this only happens if the right stimulation is given.
Where did the story come from?The study was carried out by researchers from Harvard University and several US hospitals.
Still, this research is exciting it shows that stem cells can be stimulated to form specialised cells using laser therapy, a low cost approach comparedwith existing methods.
What did the research involve?The researchers performed a number of experiments to see if dental stem cells would become dentin forming cells after stimulation with low power laser therapy. They did this on human stem cells in the laboratory Nike Air Force Ones Low Cut and on the teeth of rats and mice.
Itwas funded by a Harvard Presidential Scholarship, the Wyss Institute, Harvard Catalyst, Harvard Clinical and Translational Science Center and the Intramural Research Program, the National Center for Advancing Tranlational Sciences, the National Institute of Dental and Craniofacial Research, and the National Institutes of Health.
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