Council leader Sir Richard Leese said it was the party's first clean sweep since becoming a metropolitan borough council nearly four decades ago.
"We will regroup and do our best to make sure this never happens again. Our record of local work was swamped by the national tidal wave.
Faraz Bhatti, who won for the party in Whalley Range four years ago, defected to become Manchester's only Tory councillor. He did not stand last night and the seat also went to Labour.
A third of Manchester's 96 council seats were up for grabs. Last night's results leave the Lib Dems with 20 seats in the council chamber.
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He said: "It's been a terrible night and we've lost some really good councillors with over 120 years service to Manchester between them. The results across Greater Manchester and the north send a clear signal to the coalition that lessons need to be learned from tonight's disaster.
Liberal Democrats suffered a wipeout in a sensational night for the city's ruling Labour group.
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He said: "We've had a lot of very good, hard working candidates but this is clearly a verdict of the Manchester people on the coalition government and what I think they believe is betrayal by the Lib Dems within that coalition."
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"The people have spoken and we have to listen. Labour have had their best possible night but they shouldn't get too used to it.
Two of the seats won by the party in 2007 and up for re election this time had already passed into other hands.
Former Lord Mayor Alison Firth lost Withington after 28 years as a councillor, and John Commons saw Levenshulme fall into Labour hands, ending 26 years on the council.
"Simon has been a fantastic leader and we're all very proud of the way he fought this Nike Air Force Low Flyknit On Feet campaign."
Former city centre councillor Ken Dobson defected to become an independent. His seat was won by Labour.
The Lib Dems lost all the seats they were defending on a shocking night for the party at Manchester Central.
Paul Shannon, deputy leader of the Lib Dem group, said the result was worse than he had feared.
Evening News, Mitchell Henry House, Hollinwood Avenue, Chadderton, Oldham OL9 8EP.
Labour wins all 33 seats in Manchester as Lib Dems are wiped out
It proved a momentous count for Labour which won all 33 seats up for grabs, boosting its majority to the highest level in more than a quarter of a century.
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